叶凡，男，土家族，1992年9月生，湖南桑植人，2023年7月参加工作。2022年12月加入中国共产党，南京中医药大学中药学专业毕业，研究生学历，医学博士学位。邮箱752045146@qq.com。

研究方向：

中药及其活性成分止痒与镇痛作用机制。

学习经历：

2020.09-2023.06  南京中医药大学（博士）中药学专业

2017.09-2020.06  吉首大学（硕士）生物学（生理学方向）专业

2013.09-2017.06  吉首大学（学士）生物科学（师范）专业

代表论文：

[1] Fan Ye, Jiahua Lv, Xinyu Shen, Jian Zhang, Yingxin Zong, Chan Zhu,Yan Yang, Keke Jia, Yucui Jiang^*, Zongxiang Tang^*. Rutin ameliorates inflammatory pain by inhibiting P2X7 receptor in mast cells. Journal of Physiology and Biochemistry. 2023；79:287-295.

[2] Fan Ye¹, Yucui Jiang¹, Jian Zhang, Yingxin Zong, Mei Yu, Cuihua Chen, Chan Zhu, Yan Yang, Keke Jia, Gongxi Chen^*, Zongxiang Tang^*. Water Extract of Senecio scandens Buch.-Ham Ameliorates Pruritus by Inhibiting MrgprB2 Receptor. Journal of Inflammation Research. 2022; 15:5989-5998.

[3] Fan Ye¹, Yucui Jiang¹, Yingxin Zong, Jian Zhang, Chan Zhu, Yan Yang, Zongxiang Tang^*. PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells. Immunology Letters. 2022; 248:37-44.

[4] Fan Ye, Yucui Jiang, Yucui Jiang, Ying Du, Ye Tang, Chan Zhu, Yan Yang, Changming Wang, Yuan Zhou, Guang Yu, Xiaolin Yuan, Zongxiang Tang^*. Characteristics of compound 48/80-induced voltage-dependent currents in mouse mast cell tumor P815 cells. Acta Biochimica et Biophysica Sinica. 2019；51(11): 1182-1184.

[5] Mei Yu¹, Fan Ye¹, Chao Ma¹, Xiang Jin, Haiwang Ji, Dijun Wang, Yan Yang, Chan Zhu, Zongxiang Tang^*. Ligustrazine mitigates chronic venous disease-induced pain hyperalgesia through desensitization of inflammation-associated TRPA1 activity in DRG. Journal of Ethnopharmacology. 2022; 298:115667. (共一)

[6] Yucui Jiang¹, Fan Ye¹, Ying Du, Yingxin Zong, Zongxiang Tang^*. P2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain. Journal of Inflammation Research. 2021; 14:2913-2931.  (共一)

[7] 叶凡，贺建武，魏华，唐宗湘，陈功锡^*. 略论湘西药用植物资源保护与利用及产业发展的思路.山地农业生物学报. 2020, 39(02): 50-57.

[8] 叶凡，陈功锡，唐宗湘^*. 武陵山片区土家族医药研究综述[J]. 吉首大学学报(自然科学版). 2018, 39(01): 86-89.

[9] Jinjin Yan, Fan Ye（叶凡）, Ying Ju, Dijun Wang, Jiao Chen, Xinyu Zhang, Zhi Yin, Changming Wang, Yan Yang, Chan Zhu, Yuan Zhou, Peng Cao, Yang Xu, Guang Yu*, Zongxiang Tang*. Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4. Cell Calcium. 2021, 97: 102429.

[10] Yonglan Ruan¹, Jinying Ling¹, Fan Ye（叶凡）, Nuo Cheng, Fei Wu, Zongxiang Tang, Xiaolan Cheng*, Hongquan Liu*. Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway. International Immunopharmacology. 2021, 101: 108364.

[11] Xiao Geng, Hao Shi, Fan Ye（叶凡）, Han Du, Linnan Qian, Leying Gu, Guanyi Wu, Chan Zhu, YanYang, Changming Wang, Yuan Zhou, GuangYu, Qin Liu, Xinzhong Dong, LeiYu*, Zongxiang Tang*. Matrine inhibits itching by lowering the activity of calcium channel. Scientific Reports. 2018, 8(1): 11328.

[12] Yucui Jiang¹, Yingxin Zong¹, Ying Du¹, Miaomiao Zhang, Fan Ye（叶凡）, Jian Zhang, Yan Yang, Chan Zhu, Zongxiang Tang*. Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor. Inflammation Research. 2023, 72(5):933-945.

[13] 江玉翠，叶凡，杜莹，唐宗湘. 激活肥大细胞的相关受体及受体功能研究进展[J]. 生理学报. 2019(04):1-12.

参编书籍：

《土家医药》田华咏，张元忠，田兰. 中医古籍出版社.（2022.06）

研究课题：

[1] 主持江苏省研究生创新课题《千里光抑制过敏性接触性皮炎机制研究》. (2021-2022)

[2] 主持吉首大学研究生创新课题《抑制肥大细胞脱颗粒的止痒中药有效成分鉴定及其机制研究》. (2018-2019)

[3] 参与国家自然基金《MrgprB2在痒觉中的功能特异性分析及天然止痒药物作用机理研究》. (2018-2022)